Bordetella Pertussis is a gram-negative bacteria and the causative agent of Pertussis, more commonly known as Whooping Cough. It is a microbe that is transmitted from person to person via airborne droplets from the cough or sneeze of an infected host. According to recent estimates from the Centers for Disease Control and Prevention, Pertussis affects 30 – 50 million people each year and accounts for 300,000 deaths annually on a global basis — a profound human toll. Despite the dramatic decline in Pertussis cases and deaths in industrialized nations during the 20th Century due to public health vaccine initiatives, recent decades have witnessed a sharp increase in Pertussis cases and it is generally agreed that there is a critical need for a new and more effective Pertussis vaccine.