Whooping cough, also known as pertussis disease, induces long-lasting protection both mucosally (in the nose and nasal passages) and systemically (in the blood). Similarly, intranasal BPZE1, a live attenuated strain of B. pertussis, is designed to induce both mucosal and systemic immune responses, with the potential for more durable, effective and broader immunity compared to current intramuscular acellular pertussis vaccines.
